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1) To encourage basic and clinical research and research training to improve understanding of the mechanisms underlying diseases in the nephrologic, urologic, and hematologic systems; to promote the development of improved diagnostic tools and therapies for these diseases. Supported nephrologic research includes studies of the development, physiology, and cell biology of the kidney, pathophysiology of the kidney, genetics of kidney disorders, immune mechanisms of kidney disease, kidney disease as a complication of diabetes, effects of drugs, nephrotoxins and environmental toxins on the kidney, and mechanisms of kidney injury repair. Of special interest is improved diagnosis, prevention and treatment of chronic kidney disease and endstage renal disease, and improved approaches to maintenance dialysis therapies. Supported urological research includes basic studies of lower urinary tract cell biology, development, physiology, and pathophysiology, and clinical studies of bladder dysfunction, incontinence, pyelonephritis, interstitial cystitis, benign prostatic hyperplasia, and vesicoureteral reflux. The development of novel diagnostic tools and improved therapies, including tissue engineering strategies, for urologic disorders is a priority. Hematologic research emphasizes basic biomedical research on hematopoietic cell differentiation, metabolism of iron overload and deficiency, and the structure, biosynthesis and genetic regulation of hemoglobin as well as research on the etiology, pathogenesis, and therapeutic modalities for the anemias of chronic renal failure and other chronic diseases,. 2) To foster, via National Research Service Award (NRSA) and other training mechanisms, the training and career development of scientists interested in pursuing research in the above areas. 3) Small Business Innovation Research (SBIR) program: to increase small business participation in research in the areas described above, to increase private sector commercialization of innovations derived from Federal research and development, and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. 4) Small Business Technology Transfer (STTR) program: to stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions, to foster technology transfer between small business concerns and research institutions, to increase private sector commercialization of innovations derived from Federal research and development, and to foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation. |
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Kidney Diseases, Urology and Hematology Research
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Kidney Diseases, Urology and Hematology Research
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