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Applied Toxicological Research and Testing

Applied Toxicological Research and Testing
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EXAMPLES OF FUNDED PROJECTS
        The following projects have been supported: (1) Development of an earthworm model for analyzing xenobiotic immunotoxicity; (2) an in vivo assay of environmental toxins using magnetic resonance imaging; (3) chick embryos for detecting environmental mutagens; (4) short-term mutagen testing with human and murine cells; (5) a study of rainbow trout: a model for environmental carcinogenesis; and (6) a study of cadmium nephrotoxicity: a cell culture approach.

PROGRAM ACCOMPLISHMENTS
        In fiscal year 2005, 96 research grant awards were made, of which 20 were competing RPG applications. In addition, eight STTR and 27 SBIR awards were made, of which 26 were competing. In fiscal year 2006, it is anticipated that 99 research grant awards (including SBIR and STTR awards) will be made. Knowledge of the toxicity and carcinogenicity of chemicals has come primarily from studies conducted on individual chemicals at relatively high concentrations. The mechanistic information gained from years of studying single agents has contributed to developing a rational basis for extrapolation of experimental results to assessing risk to humans, but has not been as successful when applied to a mixture of chemicals. Rarely are people exposed to single chemicals, but rather they are exposed throughout their lifetimes to a myriad of chemicals at low concentrations. From a public health perspective, a major concern is whether an unusual toxicity could result from the interaction of two or more chemicals when individually, they are without measurable effect.

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