| EXAMPLES OF FUNDED PROJECTS |
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(1) An individual research grant using a novel systems biology approach to study the genetic basis of stroke risk in sickle cell disease. The investigators validated in a clinical setting a new type of statistical analysis method for genetic association studies based on Bayesian networks. This new method studying the clinical impact of networks of specific gene variants has yielded a model that may accurately predict stroke in other patient populations. (2) A multi-project grant to study cell adhesion mechanisms in vascular disease and thrombosis. The program is designed to advance understanding of molecular mechanisms of vascular disease and to promote development of new diagnostic, therapeutic, and preventive strategies through the collaborative efforts of scientists focused on the unifying theme of cell adhesion. Studies will span analysis of biochemistry, fine structure at atomic level detail, ex-vivo studies to analyze the effects of blood flow on adhesion and signaling, hematopoiesis, and analysis of genetically modified mice. (3) A grant for a Specialized Center of Clinically Oriented Research (SCCOR) in Transfusion Medicine and Biology. The focus is to increase our understanding of the biologic and immunologic aspects of transfusion medicine. The studies in this multi-project grant address the management of the blood supply, immunologic responses to blood components or marrow derived cells, and cellular therapy. 4) A Comprehensive Sickle Cell Center Grant that integrates clinical, translational and basic research, thereby fostering multidisciplinary collaborations directed toward the goal of finding effective therapy and ultimately a cure for sickle cell disease. (5) An Individual National Research Service Award to use in utero gene delivery to target highly proliferative hematopoietic stem cells in the fetal liver of a murine model of beta thalassemia. The fellow will train under the guidance of an accomplished mentor and will develop research skills in the important area of in utero gene transfer strategies for transduction of hematopoiet stem cells and treatment of genetic disorders of the hematopoietic system that cause ongoing morbidity and mortality in children. (6) A Small Business Innovative Research Grant to develop a rapid, accurate, cost-effective screening test to detect a broad array of bacterial contaminants in stored human red blood cells. The successful development of this technology will improve the availability and safety of the human blood supply and will have broad potential for bacterial detection applications in human diagnostic, food testing, environmental testing and other research uses. |
| PROGRAM ACCOMPLISHMENTS |
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In fiscal year 2005, 790 research grants and 79 National Research Service Awards were made. The estimates for fiscal year 2006 are 794 research grants and 79 National Research Service Awards. The estimates for fiscal year 2007 are 798 research grants and 80 National Research Service Awards. In fiscal year 2005, for new and competing renewal awards 1906 grant applications were received, and of these, 224 were awarded; 94 National Research Service Award applications were received and of these 22 were awarded. Small Business Innovation Research Awards: In fiscal year 2005, 19 Phase I and 18 Phase II awards were made. |
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Blood Diseases and Resources Research
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Blood Diseases and Resources Research
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